MyBioSource.com's Sodium-Iodide Symporter Antibody is a Mouse monoclonal antibody. The Sodium-Iodide Symporter Antibody was generated using NIS, SLC5A5, sodium iodide symporter, and TDH1 as the antigen. It reacts with Human, Mouse, and Rat. This antibody has been shown to work in applications such as: ELISA, Immunofluorescence, Immunohistochemistry, and Western Blot.
Description
Background Info: Mapped to AA 625-643 of hNIS. Apparent mol. wt of 97kD,non-glycosylated version at 68kD. Other minor bands associated with hNIS at160kDa, and degradation products at ~30 kDa, and ~15kDa.
Scientific Background: The sodium iodide symporter (NIS) is an ion pump that actively transports iodide across the basolateral membrane into thyroid epithelial cells (1, 2). This is important step in the process of iodide organificaton and the formation of triiodothyronine and thyroxine (3)